Synthesis of Diastereomeric 8‐Fluoro‐ABC‐Steroid Building Blocks

Synthesis of Functionalized Aryl-vinyl Ethers as Building Blocks and Auxiliaries in Organic Synthesis

5- hydroxyisoquinoline undergoes a smooth reaction with alkyl propiolates in the presence of triphenylphosphine (15 mol%) to produce the corresponding (E)-alkyl 3-(isoquinolin-5-yloxy) acrylate in good yields. When the reaction was performed by 2-methyl 4-hydroxyquinoline and 3-nitro 4-hydroxypyridine, similar aryl vinyl ethers were obtained.

Alkoxyallenes as building blocks for organic synthesis.

Alkoxyallenes are unusually versatile C3 building blocks in organic synthesis. Hence this tutorial review summarizes the most important transformations, including subsequent reactions and their applications in the synthesis of relevant compounds, e.g. natural products. The reactivity patterns involved and the synthons derived from alkoxyallenes are presented. Often alkoxyallenes can serve as su...

Evaluation of Updating Methods in Building Blocks Dataset

With the increasing use of spatial data in daily life, the production of this data from diverse information sources with different precision and scales has grown widely. Generating new data requires a great deal of time and money. Therefore, one solution is to reduce costs is to update the old data at different scales using new data (produced on a similar scale). One approach to updating data i...

synthesis of functionalized aryl-vinyl ethers as building blocks and auxiliaries in organic synthesis

Design and synthesis of unnatural heparosan and chondroitin building blocks.

Triazole linked heparosan and chondroitin disaccharide and tetrasaccharide building blocks were synthesized in a stereoselective manner by applying a very efficient copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction of appropriately substituted azido-glucuronic acid and propargyluted N-acetyl glucosamine and N-acetyl galactosamine derivative, respectively. The resulting suitably subst...